Fight Inflammation with Kef-flamex
Inflammation has a bad reputation, but it forms a vital part of our bodies defence mechanisms. Our immune system recognizes damaged cells and pathogens, and as part of this process inflammation is needed to support healing. Acute inflammation is important for our health, but there is a more harmful form of inflammation known as chronic inflammation which can silently simmer over the course of years and have profound implications for health.
Chronic inflammation and associated diseases like rheumatoid arthritis and osteoarthritis are primarily caused by corrupted signalling and responses at a cellular level, which causes the immune system to become stuck. To manage chronic inflammation and these conditions we need to repair the corrupted signalling, reset the immune system, reduce inflammation and its potential causes and protect the tissues. There are a number of ways we can support our defence against this chronic inflammation including diet and lifestyle. It’s also important that we support our gut flora as 70% of our immune system is within the gut and our microbes can help to re-regulate our immune system and influence its signalling. Alongside this we can utilise powerful medicinal foods and herbs which have anti-inflammatory and anti-oxidant properties to support our health.
One of the most well-known anti-inflammatory herbs is turmeric and in its fermented form it is highly bioavailable. Fermented turmeric works effectively on the pro-inflammatory COX and LOX enzyme pathways. It also produces significantly greater secretion of the anti-inflammatory compound IL-10 which facilitates tissue integrity and healing, and reduced secretion of pro-inflammatory compounds TNFa and IL-6, which are 2 signalling cytokines that are implicated in the chronic inflammatory conditions mentioned above. Fermented turmeric also contains nearly 1000% more “tetrahydro-curcumin” than unfermented forms, and this is more efficient than its curcumin analogue at reducing inflammation and regulating the immune system signalling to bring the body back into balance (1;2;3). Tetrahydro-curcumin differs from curcumin in its molecular targets, signalling pathways and cellular responses (4) and appears to be better at targeting and reversing the conditions associated with inflammation.
Holy Basil is another herb that is a potent antioxidant and very beneficial at protecting cells and tissues from damage caused by toxins, the environment and chronic inflammation. It reduces stress triggers which keep the immune system activated and out of balance. It is also a powerful anti-inflammatory working on the COX and LOX pathways just like turmeric.
Green Tea is another strong anti-inflammatory herb, and has been used in Traditional Chinese Medicine (TCM) for centuries to support health. It is rich in at least 51 different antioxidant compounds and demonstrates anti-inflammatory effects (6). It also possesses unique compounds to support the signalling process and contribute to anti-inflammatory and anti-arthritic activity in the joints (7).
For all round immune support, we can’t forget the power of mushrooms. Medicinal mushrooms are best known for their immune-modulatory effects which can be beneficial in these chronic inflammatory conditions. Reishi is the most researched mushroom for managing inflammation, working on the histamine pathways, re-regulating the immune response at a stem cell level and influencing immune signalling. It helps to prevent flare ups of tissues and protects against an over-reactive immune system (5). It contains highly active immune-modulating polysaccharides and over 130 anti-inflammatory triterpenoid compounds.
There is so much more to managing these chronic inflammatory conditions than masking the pain with medication. A little herbal support can help to target the root cause of these conditions rather than just addressing the symptoms. Kef-flamex’s unique blend of of fermented Turmeric, Holy basil, Green tea, Rosemary, Ginger plus Reishi mushroom, can help regulate the immune system, promote a healthy inflammatory response and provide powerful antioxidants to bring our body back into balance.
1.Epstein, J., Sanderson, IR., MacDonald, TT. 2010. ‘Curcumin as a therapeutic agent: the evidence from in vitro, animal and human studies.’ British Journal of Nutrition, 103 (11), 1545-1557. https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/curcumin-as-a-therapeutic-agent-the-evidence-from-in-vitro-animal-and-human-studies/225164D1A70D11C765C147A5CD022200/core-reader
2.Pianpumepong, P., Kumar Anal, A., Doungchawee, G. et al. 2012. ‘Study on enhanced absorption of lactobacillus-fermented turmeric (Curcuma longa Linn.) beverages in rats.’ International Journal of Food Science and Technology, 47(11), 2380-2387: http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2621.2012.03113.x/abstract
3.Portes, E., Gardrat, C. and Castellan, A. 2007. ‘A comparative study on the antioxidant properties of tetrahydrocurcuminoids and curcuminoids. Tetrahedron, 63, 9092-9099: http://castellan-publicatio.monsite-orange.fr/file/e74b48a4ec9894d6718b424e7583c857.pdf .
4: Aggarwal, BB., Deb, L,. and Prasad, S. 2015. ‘Curcumin Differs from Tetrahydrocurcumin for Molecular Targets, Signaling Pathways and Cellular Responses’. Molecules, 20(1), 185-205: http://www.mdpi.com/1420-3049/20/1/185/htm
5: Aggarwal, BB., Deb, L,. and Prasad, S. 2015. ‘Curcumin Differs from Tetrahydrocurcumin for Molecular Targets, Signaling Pathways and Cellular Responses’. Molecules, 20(1), 185-205: http://www.mdpi.com/1420-3049/20/1/185/htm
6: Rong-Hwa, J., Teng-Yi, L., and Yu-Li, L. 2011. ‘ Immuno-modulatory activity of Ganoderma lucidum-derived polysacharide on human monocytoid dendritic cells pulsed with Der p 1 allergen’ BMC Immunology 12(31): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127845/